Biolog Webinar: 8th June 2022 | 4:30pm
Biolog invites you to a special webinar featuring our guest speaker:
Dr. Dzmitry Mukh | Postdoctoral Research Fellow – The Wistar Institute
Tumour Growth Maintained by Mitochondrial Protein Lipoylation: The Role of Glycine Decarboxylase
Webinar Topics Include
- A metabolic systems biology approach was employed to study the role of the glycine cleavage system (GCS) and glycine decarboxylase (GLDC) in hepatocellular carcinoma (HCC)
- HCC exhibits high expression of GCS genes and high glycine cleavage metabolic flux
- MitoPlate™ analysis of GLDC-silenced cells demonstrated a decrease in pyruvate and α-ketoglutarate oxidation caused by decreased lipoylation of mitochondrial enzymes
- Genetic silencing of GLDC impairs tumour growth, suggesting a novel drug target for HCC