Biolog Webinar: 8th june 2022 | 4:30pm

Biolog invites you to a special webinar featuring our guest speaker:
Dr. Dzmitry Mukh | Postdoctoral Research Fellow – The Wistar Institute

TUMOUR GROWTH MAINTAINED BY MITOCHONDRIAL PROTEIN LIPOYLATION: THE ROLE OF GLYCINE DECARBOXYLASE

Webinar Topics Include

  • A metabolic systems biology approach was employed to study the role of the glycine cleavage system (GCS) and glycine decarboxylase (GLDC) in hepatocellular carcinoma (HCC)
  • HCC exhibits high expression of GCS genes and high glycine cleavage metabolic flux
  • MitoPlate™ analysis of GLDC-silenced cells demonstrated a decrease in pyruvate and α-ketoglutarate oxidation caused by decreased lipoylation of mitochondrial enzymes
  • Genetic silencing of GLDC impairs tumour growth, suggesting a novel drug target for HCC
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